Which of the following conditions is associated with predisposed cervical instability?

• A. Marfan Syndrome
• B. Multiple Sclerosis
• C. Down Syndrome
• D. Cystic Fibrosis

Answer: (A)

Marfan Syndrome is a connective tissue disorder characterized by features such as tall stature, long limbs, and attention to various organ systems, including the cardiovascular and skeletal systems. One of the key issues associated with Marfan Syndrome is a deficiency in the structural proteins that maintain the integrity of connective tissues. This can lead to abnormalities in the spine and potentially predispose individuals to cervical instability, which is a situation where the cervical vertebrae are unable to maintain their proper alignment and stability.

Cervical instability can result in neurological symptoms due to spinal cord compression, making it a significant concern in patients with Marfan Syndrome. This condition necessitates careful monitoring and management to prevent complications associated with instability.

While multiple sclerosis, Down syndrome, and cystic fibrosis can have a range of neurological or systemic implications, they are not directly associated with the same degree of cervical instability as seen in Marfan Syndrome, making the latter the most appropriate choice in this context.